Covaris Adaptive Focused Acoustics^® (AFA^®) technology enables precise, reproducible DNA fragmentation, supporting consistent coverage, high mapping rates, and unbiased CpG representation across sample types and input levels. This enables high-confidence variant calling and accurate methylation profiling in workflows leveraging the Illumina 5-base genome solution. For challenging sample types such as FFPE, Covaris truXTRAC^® workflows enable the extraction of high-quality DNA, providing a reliable foundation for downstream fragmentation and multiomic sequencing.

Validated performance with Illumina 5-base workflows:

• Consistent coverage and mapping performance across instruments and input amounts

• High concordance in methylation detection across conditions

• Unbiased GC and CpG coverage for accurate multiomic profiling

• High sensitivity and precision in variant detection

• Robust performance across sample types, including FFPE and tumor samples

• Reliable DNA recovery from FFPE samples using truXTRAC^® extraction workflows

Access the AACR 2026 Product Theater Presentation →
Featuring Greg Endress, Covaris SVP of Technology and Innovation and Smriti Sharma, PhD Illumina Staff Product Manager-  Multiomic Library Prep Team

Contact us to learn how Covaris enables precision fragmentation for multiomic accuracy.